For severe yeast infections, your doctor may prescribe an antifungal vaginal cream. He or she may also prescribe a steroid cream for a few days to ease more severe inflammation, redness, and soreness of the opening of the vagina and the surrounding tissue, called the "vulva.” Vaginal creams usually come packaged with an applicator that helps you measure the right dose. A range of yeast infection medications are available without a prescription. Some are creams you apply inside the vagina. Others are suppositories or vaginal tablets you place in your vagina and let dissolve.