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  • Benzodiazepines suppress muscle contractions and help you sleep through the movements. Clonazepam (Klonopin) is probably the most widely used drug to treat PLMD.
  • Dopaminergic agents raise levels of the neurotransmitter dopamine, which is important in regulating muscle movements.
  • Anticonvulsant agents reduce muscle contractions in some people.
  • GABA agonists prevent the release of certain neurotransmitters that stimulate muscle contractions.
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