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COMT inhibitors add to the amount of time you get relief from symptoms by blocking the action of an enzyme that breaks down levodopa. You take these drugs, such as entacapone (Comtan) and tolcapone (Tasmar), along with levodopa. Tolcapone is rarely prescribed by doctors, though, because it can cause liver damage.

Stalevo is a tablet that combines carbidopa/levodopa with entacapone. While carbidopa lessens the side effects of levodopa, entacapone adds to the time levodopa is active in the brain.

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