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Researchers are studying the incidence of breast lumps in women using hormone replacement therapy (HRT). In combination HRT, women take the hormones estrogen and progestin to ease the symptoms of menopause. In 2002, a study called the Women’s Health Initiative discovered that HRT resulted in more harm than good. Taking both hormones was shown to increase the risk of breast cancer and change the breast's structure, increasing breast density and making mammograms harder to read. This could make finding cancer more difficult. To put this into numbers, if 10,000 women took combined HRT for a year, this would add up to about 8 more cases of breast cancer per year than if they had not taken hormone therapy (HT).

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