Vaginal creams go inside the vagina to kill off the yeast that cause yeast infections. Sometimes called antifungal creams, these products usually come with an applicator that measure the right dose. Some vaginal creams can be messy and leak out of the vagina during the day, so you’ll only want to use them at bedtime. Some of these products may come with a cream that you put on the opening of the vagina and surrounding tissue (called the "vulva") and not into the vagina. This type of cream may ease itching and treat the skin tissues while the vaginal antifungal cream treats the yeast infection. When you use a vaginal cream that’s oil-based, you may need to use birth control that’s not a condom or diaphragm, or skip sex. The oil in the cream could damage the latex in a condom or diaphragm.