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Most breast pain seems to relate to the levels of two hormones -- estrogen and progesterone -- in your body. Doctors aren’t sure what triggers breast pain. It can happen at different times in your reproductive life, such as during:

  • Puberty
  • Your monthly period or when you have premenstrual syndrome (PMS)
  • Pregnancy, usually in the first trimester
  • Breastfeeding. Sometimes a blocked milk duct can get infected, a painful condition called mastitis. It needs to be treated immediately, usually with antibiotics.
  • Menopause
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