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There are no reported side effects of L-citrulline. However, the supplement may affect the way certain drugs work in your body. Do not take this supplement if you are taking:

Combining L-citrulline with those drugs may cause a dangerous drop in blood pressure. Also, you should also be careful when taking L-citrulline if you take any type of blood pressure medicine. Do not use L-citrulline if you are pregnant or breastfeeding. Always tell your doctor about any supplements you are taking.

  • Nitrates for heart disease
  • Erectile dysfunction drugs such as Cialis, Levitra, or Viagra

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