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Taking CLA may cause upset stomach, nausea, diarrhea, and fatigue.

CLA supplements may worsen insulin resistance if you have diabetes or metabolic syndrome. It may cause "fatty liver" or other liver problems and lower HDL "good" cholesterol. It might raise inflammation.

CLA could cause trouble with drugs for schizophrenia and other mental disorders as well as with blood thinners and high blood pressure medicines.

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