Treatment may also include drugs such as darifenacin (Enablex), desmopressin acetate (Noctiva), imipramine (Tofranil), mirabegron (Myrbetriq), oxybutynin (Ditropan), oxybutynin (Oxytrol), solifenacin (Vesicare). tolterodine extended-release (Detrol LA), and trospium extended-release (Sanctura XR).
Oxytrol for women is the only drug available over the counter. Darifenacin is presecribed specifically for people who wake up more than twice a night to urinate.