- Benzodiazepines suppress muscle contractions and help you sleep through the movements. Clonazepam (Klonopin) is probably the most widely used drug to treat PLMD.
- Dopaminergic agents raise levels of the neurotransmitter dopamine, which is important in regulating muscle movements.
- Anticonvulsant agents reduce muscle contractions in some people.
- GABA agonists prevent the release of certain neurotransmitters that stimulate muscle contractions.
Many of these medications are also used to treat restless legs syndrome.