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How can gamma-aminobutyric acid (GABA) agonists help with treating periodic limb movement disorder (PLMD)?

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GABA agonists are medicines that curb the release of certain neurotransmitters that stimulate muscle contractions. The result is relaxation of contractions. The most widely used of these agents in periodic limb movement disorder (PLMD) is baclofen (Lioresal).

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