Yeast infection treatment depends on the specific kind of infection that is being treated. Skin yeast infections are highly treatable with medicated creams. Medicated suppositories may be used to treat yeast infections in the vagina. Thrush may be treated with a medicated mouthwash or lozenges that dissolve in the mouth. Severe infections or infections in someone with a compromised immune system may be treated with oral anti-yeast medications.