Systemic psoriasis treatments, working on the entire body, often act on the immune system to reduce psoriasis activity over large areas of the body. These are used to treat moderate to severe psoriasis. Advanced psoriasis treatments include:
While systemic psoriasis treatments are far more effective than topical creams, they also have more potential side effects and are more expensive.
Oral drugs (pills) such as acitretin (Soriatane), apremilast (Otezla), cyclosporine, and methotrexate (Trexall).
Biologic therapies, including adalimumab (Humira), brodalumab (Siliq), etanercept (Enbrel), etanercept-szzs (Erelzi), infliximab (Remicade), ixekizumab (Taltz), secukinumab (Cosentyx) and ustekinumab (Stelara). These are injectable drugs.
Phototherapy, or ultraviolet light treatment to the whole body.