When regular antiperspirants fail to treat excessive sweating, most doctors start by recommending aluminum chloride hexahydrate (Drysol), a prescription-strength version of aluminum chloride. It is applied just before bedtime 2 to 3 nights in a row, then roughly once a week thereafter to maintain improvement. Use as directed by your doctor.This treatment works reasonably well for many patients whose problem is excessive underarm sweating, but it is not satisfactory for most of those with palm and sole sweating.