Psoriatic arthritis is treated much like rheumatoid arthritis. Common treatment includes drugs that might slow the process of joint damage in psoriatic arthritis (called disease-modifying antirheumatic drugs or DMARDs); and nonsteroidal anti-inflammatory drugs (NSAIDs), which treat symptoms without changing the course of psoriatic arthritis. The drug apremilast (Otezla) doesn't fall into either of the above categories. It's an inhibitor of an enzyme called phosphodiesterase-4 (PDE-4). Otezla is FDA-approved to treat psoriatic arthritis and is taken orally.