The physical causes of male sexual dysfunction include:
Premature ejaculation (PE) is usually not due to physical causes, although the problem is sometimes linked to a neurological disorder, prostate infections, or urethritis.
Diabetes, especially if you have type 2
Hypogonadism, in which the testicles do not produce enough testosterone
Thyroid disorders
Adrenal lesions (Cushing's syndrome)
Noncancerous pituitary growths that increase levels of a hormone called prolactin
Diseases that affect the nervous system
Damage following pelvic surgery
Conditions or injuries that affect the penis directly
Any serious and debilitating disease that results in intense fatigue