Sometimes, biologic drugs will help you for a while and then don't work as well. It's not clear why. If it happens to you, tell your doctor. He'll probably switch you to another biologic or add another type of rheumatoid arthritis (RA) drug, like methotrexate or sulfasalazine, so your treatment works better.
Some people get more help from biologics than others. Experts can't predict who'll respond well and who won't. But they know that people who get treatment in the earlier stages of RA tend to do better than those who've had the disease for many years.
Biologics also work best if you take them on a regular schedule. If you can't do that due to side effects or the cost of the drugs, ask your doctor about your options.