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  • Methotrexate can also: Cause lung problems. Tell your doctor if you cough frequently or have shortness of breath.
  • Make lymphoma (cancer of the lymphatic system) more likely.
  • Make your skin more sensitive to the sun. Use sunscreen, wear protective clothing, and don’t use sunlamps or tanning beds.
  • Cause birth defects. If you or your partner could get pregnant, you should use birth control while on methotrexate. Men should continue to use protection for 3 months after the last dose. Women should stay on birth control for at least 1 menstrual cycle after the last dose and not breastfeed while taking methotrexate.

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