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You can take methotrexate in either pills or shots. There are prefilled methotrexate shots that are easy to take at home.

You will take 7.5 to 10 milligrams each week. Your doctor may raise that to as much as 25 milligrams per week if needed.

The pills will come with directions about how many to take and when. If you’re not sure about those instructions, ask your doctor or a pharmacist.

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