You’re more likely to get an infection while you take methotrexate. So take these steps to stay well: 1. Try to avoid people with infections like colds or flu.
2. Wash your hands regularly.
3. Tell your doctor if you have fever, chills, or a cough.
4. Don’t take live vaccines like the nasal flu mist, measles, mumps, or shingles shots while you take methotrexate.