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Sometimes, the use of certain drugs can cause side effects that mimic the symptoms of Sjögren's syndrome. Medications such as tricyclic antidepressants (like Elavil or Pamelor) and antihistamines like Benadryl, radiation treatments to the head and neck, as well as other autoimmune disorders, can also cause severely dry eyes and mouth, but it’s not Sjögren’s syndrome.

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