There are also many strong medications called disease-modifying antirheumatic drugs (DMARDs) that work by interfering with or suppressing the immune system's attack on the joints. They include:
- Hydroxychloroquine (Plaquenil), originally used to treat malaria
- Immune suppression drugs, such as methotrexate
- Biologic treatments, such as abatacept (Orencia); adalimumab (Humira), adalimumab-atto (Amjevita), a biosimilar to Humira; anakinra (Kineret); certolizumab (Cimzia); etanercept (Enbrel); etanercept-szzs(Ereizi), a biosimilar to Enbrel; golimumab (Simponi and Simponi Aria); infliximab (Remicade); infliximab-dyyb (Inflectra), a biosimilar to Remicade; rituximab (Rituxan); sarilumab (Kevzara); andtocilizumab (Actemra),
- Other drugs, such as leflunomide (Arava), sulfasalazine (Azulfidine), tofacitinib (Xeljanz), and upadacitinib (Rinvoq)