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If the first anti-TNF you try doesn't work for you, your doctor will most likely try another one. If you still don't get relief, he may switch you to another type of biologic. These include:

  • Abatacept (Orencia), which blocks the immune system's T cells to lower inflammation
  • Anakinra (Kineret), which targets interleukin-1, a chemical your body makes that causes inflammation. Your doctor will call this type of drug an "IL-1 blocker."
  • Rituximab (Rituxan), which targets certain B cells, which are part of your immune system
  • Tocilizumab (Actemra), which targets IL-6, a chemical your body makes that causes inflammation. Your doctor will call this type of drug an "IL-6 blocker."

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