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The formula for treating rheumatoid arthritis (RA) often is a mix. Doctors draw from three main groups of FDA-approved medicines:

1. Nonsteroidal anti-inflammatory drugs (NSAIDs) ease pain and inflammation. Some, like ibuprofen and naproxen sodium, are over-the-counter drugs. You need a prescription for others, including a kind called COX-2 inhibitors, which can be easier on your stomach.

2. Corticosteroids, including prednisone, act quickly to control inflammation. These strong drugs have strong side effects, so doctors limit the dose and how long you take them.

3.Disease-modifying antirheumatic drugs (DMARDs) can alter the course of RA and prevent joint and tissue damage. They block the effects of chemicals released when your immune system mistakenly attacks your joints. Methotrexate is usually the first DMARD prescribed, often as soon as someone is diagnosed. Doctors now know that a delay might make your RA worse.

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