You may be tempted to skip your medications on days when you’re feeling better. Don’t do that. Missing a dose could cause the pain to return, and it may be harder to get relief later. Your rheumatoid arthritis (RA) could also worsen. Some drugs need to stay in your bloodstream at specific levels in order to be effective. If you skip them too often, blood levels of the medication will drop and you could end up with a flare-up of your RA.