Biologic drugs used to treat rheumatoid arthritis (RA) include abatacept (Orencia), adalimumab (Humira), anakinra (Kineret), certolizumab (Cimzia), etanercept (Enbrel), etanercept-szzs (Ereizi), golimumab (Simponi, Simponi Aria), and infliximab (Remicade). These are the newest drugs for RA and are either injected under the skin or given directly into a vein. They work by neutralizing one of the immune system's signals (TNF) that lead to inflammation and joint damage. Rituximab (Rituxan) and tocilizumab (Actemra) are biologics but do not block TNF. Rituxan target B cells and actemra affects IL-6.