Upset stomach, indigestion, and headaches are the most common side effects of taking oral anti-inflammatory drugs. However, taking these medications after meals or with food can help reduce stomach upset. Anti-inflammatory drugs can also cause vomiting, constipation, and bleeding in the stomach (ulcers), although these side effects are not common.
Side effects of cortisone shots depend on the dose and frequency of the injections. Unlike cortisone pills, occasional cortisone injections rarely cause serious side effects. Side effects that are much more common with cortisone pills include elevated blood sugar, a decrease in the body's resistance to infection, weight gain, osteoporosis, thinning of the skin, cataracts, and raised blood pressure.