Your doctor may prescribe methotrexate alone, or you may also take other drugs like aspirin, nonsteroidal anti-inflammatory drugs, low-dose steroids, or other disease-modifying antirheumatic drugs (DMARDs).
You’ll probably take folic acid supplements along with methotrexate. This vitamin can help you lower your chance of certain side effects.
Talk to your doctor before you take any drug or supplement. Not all drugs mix well.