Slow-acting anti-rheumatic drugs (SAARDs) are used to treat pain and swelling over time and usually take several weeks or more to work. These drugs are also called disease-modifying anti-rheumatic drugs (DMARDs). The doctor may prescribe drugs in this category in combination with nonsteroidal anti-inflammatory drugs. Lab tests to check for possible side effects are usually necessary. One of the most commonly used DMARDs is methotrexate (Rheumatrex). Other DMARDs include hydroxychloroquine (Plaquenil), sulfasalazine (Azulfidine), and drugs that block tumor necrosis factor (TNF), also called anti-TNF drugs. Etanercept (Enbrel) and etanercept-szzs (Erelzi) are examples of anti-TNF medication used to treat juvenile arthritis.