Disease-modifying anti-rheumatic drugs (DMARDs) are often used if nonsteroidal anti-inflammatory drugs (NSAIDs) don't provide enough relief. DMARDs may keep juvenile rheumatoid arthritis (JRA) from getting worse, but because they take weeks or months to relieve symptoms, they’re often taken with an NSAID. Methotrexate is usually the main DMARD doctors prescribe for JRA.