Other medical conditions linked to restless legs syndrome (RLS) include:
a. Alcohol
b. Caffeine
c. Anticonvulsant drugs (such as Dilantin)
d. Antidepressant drugs (including amitriptyline, Paxil)
e. Beta-blockers (drugs often used to treat high blood pressure)
f. Antipsychotics
Parkinson's disease
Varicose veins
Some tumors
Fibromyalgia
Hyper- or hypothyroidism (over- or underactive thyroid glands)
Pregnancy
Cigarette smoking
Vitamin and mineral deficiency, such as magnesium deficiency and vitamin B-12 deficiency
Severe kidney disease and uremia (kidney failure causing build up of toxins within the body)
Amyloidosis (build-up of a starch-like substance in the body's tissues and organs)
Lyme disease
Damage to spinal nerves
Rheumatoid arthritis and Sjögren syndrome
Certain medications or substances, such as:
g. Withdrawal from certain drugs, such as vasodilator drugs (for example, Apresoline), sedatives, or antidepressants (for example, Tofranil)