Nonsteroidal anti-inflammatory drugs, like naproxen and ibuprofen, can help with inflammation and pain. If the enthesitis is caused by an autoimmune arthritis, your doctor also may prescribe a disease-modifying anti-rheumatic drug, such as methotrexate, or biologics such as adalimumab (Humira), etanercept (Enbrel), or infliximab (Remicade). Your doctor may recommend steroids for areas that are especially stiff or painful.