If you have generalized or Von Zumbusch psoriasis, get medical care right away. You'll need fluids, and get treatments to prevent infection, ease your fever, and calm inflamed, broken skin. While you're in the hospital, you need to rest, stay hydrated, and keep cool. Your doctor may try acitretin, methotrexate, cyclosporine, steroids, or biologics (drugs made from living cells) like etanercept or infliximab to get your flare under control. Once your skin redness and pustule outbreaks have calmed down, you can also try PUVA, where you take a drug called psoralen and then beam ultraviolet light at the affected area of your skin.