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Some medications can make psoriasis worse. These include:

  • Lithium, which treats bipolar disorder and other mental illnesses
  • High blood pressure and heart medicines, including propranolol (Inderal) and other beta blockers, ACE inhibitors, and quinidine
  • Antimalarial medicines, including chloroquine, and hydroxychloroquine (Plaquenil), and quinacrine
  • Indomethacin (Indocin), which treats inflammation
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