Psoriasis, especially if it's severe, seems to make you more likely to have a heart attack or stroke. Treating it can lower your risk, but some medications can hurt more than they help. Both cyclosporine and acitretin (Soriatane) can raise your cholesterol levels. Cyclosporine can also raise your blood pressure. And you shouldn't mix it with a kind of high blood pressure medication called a calcium channel blocker. People with congestive heart failure shouldn't take certain biologics, including etanercept (Enbrel), adalimumab (Humira), and infliximab (Remicade).