Nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen (Motrin, Advil) and naproxen (Aleve) are staples in the treatment of cervical disc disease because they reduce both pain and inflammation. Like acetaminophen, many NSAIDs are available over-the-counter, but they also need to be taken carefully. NSAIDs can have some serious side effects, such as gastrointestinal bleeding, ulcers, and kidney damage, especially when used for long periods of time. NSAIDs have also been linked to an increased risk of heart attack or stroke.