You can relieve osteoarthritis at home. Make sure you get enough rest. While it's important to stay active, give your joints time off when they hurt. You can also try acetaminophen (Tylenol) and anti-inflammatory drugs like ibuprofen (Advil, Motrin) or naproxen (Aleve) if your doctor says these are safe for you. They provide fast relief for mild to moderate arthritis pain.