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The disease-modifying drugs cladribine (Mavenclad), mitoxantrone (Novantrone), and siponimod (Mayzent)  have been approved to treat SPMS. Mitoxantrone is still mainly works to treat relapses and has serious side effects, including problems and . So there’s a limit to how much people can use it in their lifetimes. It’s usually for people with disease that gets worse quickly when other treatments don't work. heartleukemia

Mitoxantrone has serious side effects, including heart problems and leukemia, so there’s a limit to how much people can use it in their lifetimes. It’s usually for people with disease that worsens quickly when other treatments don't work.

Methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), a medication often used to treat rheumatoid arthritis, may improve symptoms in people with SPMS.

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