You can get plasma exchange in the hospital or at an outpatient center. The process isn't painful, and you won't need anesthesia.
You'll lie in bed or sit in a reclining chair.
A nurse or a specialist will put a needle attached to a thin tube, called a catheter, into a vein in each arm. If your arm veins are too small, you may have to have a needle in your shoulder or groin instead.
Your blood comes out through one of the tubes and goes into a machine that separates your plasma from your blood cells. Then, your blood cells get mixed with fresh plasma, and the new blood mixture goes back into your body through the other tube.
Most treatments last 2 to 4 hours, depending on your size and how much plasma gets swapped out. You may need two or three treatments each week for at least 2 weeks.