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Most people with primary progressive multiple sclerosis (PPMS) first have trouble walking, and after many years, both legs may become stiff and weak. Many also have mild problems with their memory or thinking clearly. You may get other symptoms, too, such as fatigue, muscle stiffness (spasticity), and numbness, pain, or a "pins and needles" feeling.

While you won't know exactly what's going to happen next and you won't be able to repair your nerves, you can ease your symptoms and lessen the impact of the disease.

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